化学名称 D-伪麻黄碱
外观 晶体 (乙醚)
化学物质登录号 90-82-4
分子式
分子量 165.23
植物来源
生物活性
鉴定 熔点 118°C
旋亮度 [α]20D+52°
UV
IR
ESI-MS
1HNMR
13CNMR
分析方法
仪器 硅胶G 板 (Qingdao Haiyang Chemical Co., Ltd)
流动相 氯仿: 甲醇: 浓氨水 = 20: 5: 0.5
检测器 UV λ360 nm
仪器 Agilent (Palo Alto, CA) 1100 series HPLC 仪配备 AppliedBiosystems (FosterCity, CA) API-4000 三重四极杆质谱及 TurboIonSpray® (电喷雾) 源
色谱柱 Waters (Milford, MA) Xbridge 苯柱 (150 mm × 2.1-mm i.d., 3.5-µm), Waters Xbridge 苯保护柱 (10 mm × 2.1-mm i.d.)
流动相 A: 10 mM pH 5乙酸铵, B: 甲醇 (流动相B), 0.3 mL/min
检测器 电喷雾电离源, 正离子模式, 多反应检测 (MRM). 离子转换: 166 -133. 离子喷雾: 5000 V, 源温度: 650°C, 界面加热. 气压: 10 psi, 雾化气压: 60 psi, 辅助气压: 50 psi.
仪器 Thermo Separation Products 仪 (Riviera Beach, FL, 漩涡混合4 ml己烷, USA).
色谱柱 5034 mm I.D. 色谱柱 (Watrex, Prague, Czech Republic) 3 min 离心分离相并过滤 Nucleosil 120-5 C18 2600 g 固定相, 80 ml 下相, 粒径 5 mm
流动相 乙腈-磷酸- 自动进样阀. 进样 30ml 0.1% 三乙胺磷盐缓冲液, pH2.4, 磷酸 (5: 95, v/v). 流率2 mL/min, 358°C
检测器 λ195 nm 检测波长, 保持时间 1 s
参考文献
[1] Krizevski, R., et al. (2010). "Composition and stereochemistry of ephedrine alkaloids accumulation in Ephedra sinica Stapf." Phytochemistry 71(8-9): 895-903.
[2] Hanes, A., et al. (2013). "Pseudoephedrine for the treatment of clozapine-induced incontinence." Innov Clin Neurosci 10(4): 33-35.
[3] Nudmamud-Thanoi, S. and S. Thanoi (2012). "Pseudoephedrine induces sperm abnormalities, lower sperm counts and increased apoptosis in rat testis." Cell Tissue Res 349(2): 625-630.
[4] Minamizawa, K., et al. (2006). "Effect of d-pseudoephedrine on cough reflex and its mode of action in guinea pigs." J. Pharmacol. Sci. (Tokyo, Jpn.) 102(1): 136-142.
[5] Cooper, S. D., et al. (2011). "Determination of L-ephedrine, pseudoephedrine, and caffeine in rat plasma by liquid chromatography-tandem mass spectrometry." J Anal Toxicol 35(6): 341-348.
[6] Macek, J., et al. (2002). "Rapid determination of pseudoephedrine in human plasma by high-performance liquid chromatography." Journal of Chromatography B 766(2): 289-294.
[7] Zhao, Z., et al. (2006). "Study on quality standard for Maxing Zhike capsules." Zhongguo Yaopin Biaozhun 7(6): 51-54.
连结 中药材图像数据库 药用植物图像数据库 中药标本数据库

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