化学名称 L-天仙子胺
外观 白色晶体粉末
化学物质登录号 101-31-5
分子式
分子量 289.167794
植物来源
生物活性
鉴定 熔点 108.5°C
旋亮度 [α]20D-21° (乙醇)
UV
IR
ESI-MS
1HNMR
13CNMR
分析方法
仪器 20 × 20 硅胶铝板60 F254 (Merck, Darmstadt, Germany)
流动相 氯仿: 甲醇: 氨水 (44: 9: 1)
仪器 LC-6A HPLC 泵配备SPD-6AV UV 检测器 (Shimadzu)
色谱柱 C18 色谱柱 (3.9 × 300 mm, 5 μm) (Novapak)
流动相 A: 乙腈, B: 5 mM SDS, 40% A, v/v, pH 3.5, 1.1 mL/min
检测器 UV λ204 nm
仪器 1100 LC/MSD 液相色谱质谱系统 (Palo Alto, CA, USA)
色谱柱 Chirobiotic V 色谱柱 (250 × 4.6 mm, 5 um), Chirobiotic V 保护柱 (2 cm × 4.0 mm, 5 um) (Astec, Advanced Separation Technologies Inc., Whippany, NJ, USA)
流动相 甲醇: 乙酸: 三乙胺 (0-25 min, 100: 0.05: 0.04-100: 0.05: 0.1, v/v/v, 1 mL/min)
检测器 大气压化学离子接口 (APCI), 正离子模式, 干燥气: 350°C, 蒸汽温度: 210°C, 毛细管电压: 4000 V, 碎片: 70 V
仪器 A GC Varian mod. 3300/3400 仪
色谱柱 毛细管柱J. & W. OV1 (15 × 0.25 mm, 0.25 μm), 100°C 1 min, 280°C 30 min. 多支管: 220°C, 注射器: 280°C, 转移线: 290°C
检测器 Finnigan Mat mod. ITS 40 质谱及离子阱全扫描 (40-500 amu)
参考文献
[1] Pramod, K. K., et al. (2010). "Biochemical and structural characterization of recombinant hyoscyamine 6β-hydroxylase from Datura metel L." Plant Physiology and Biochemistry 48(12): 966-970.
[2] el Jaber-Vazdekis, N., et al. (2009). "Cloning, characterization and analysis of expression profiles of a cDNA encoding a hyoscyamine 6β-hydroxylase (H6H) from Atropa baetica Willk." Plant Physiology and Biochemistry 47(1): 20-25.
[3] Ghelardini, C., et al. (2000). "Pro-cognitive activity induced in the rat by low doses of R-(+)-hyoscyamine." Fitoterapia 71, Supplement 1(0): S124-S130.
[4] Ghelardini, C., et al. (1997). "Stereoselective Increase in Cholinergic Transmission by R-(+)-hyoscyamine." Neuropharmacology 36(3): 281-294.
[5] Rozear, M., et al. (1968). "Effects of intracerebroventricular L-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside." International Journal of Neuropharmacology 7(1): 1-IN3.
[6] Rocha, P., et al. (2002). "Functional expression of tropinone reductase I (trI) and hyoscyamine-6β-hydroxylase (h6h) from Hyoscyamus niger in Nicotiana tabacum." Plant Science 162(6): 905-913.
[7] Siluk, D., et al. (2007). "HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma." Journal of Chromatography B 859(2): 213-221.
[8] Miraldi, E., et al. (2001). "Distribution of hyoscyamine and scopolamine in Datura stramonium." Fitoterapia 72(6): 644-648.
连结 中药材图像数据库 药用植物图像数据库 中药标本数据库

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